Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE).
نویسندگان
چکیده
A vancomycin (Van) derivative self-assembles in a phosphate buffer as a divalent Van and on cell surfaces as a multivalent Van, which offers potent activity against VRE.
منابع مشابه
Multivalent antibiotics via metal complexes: potent divalent vancomycins against vancomycin-resistant enterococci.
Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H(2)O)(2)](2+), exhibit potent activities (MIC approximately 0.8 mug/mL, approximately 720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.
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ورودعنوان ژورنال:
- Chemical communications
دوره 17 شماره
صفحات -
تاریخ انتشار 2003